„Young biochemistry“

17 June, 2014 | Birštonas


Virginijus Šikšnys

(IBT VU, Vilnius)

Dr. Virginijus Šikšnysstudied chemistry at Vilnius University and obtained his Ph.D. from Moscow University. Later he moved through different research ranks at the Institute of Applied Enzymology/Institute of Biotechnology in Vilnius. Currently he is chief scientist/Department head at the Institute of Biotechnology of Vilnius University and serves as a Chairman of the Institute`s Board. Since 2005 he holds a position of Professor of Vilnius University. He is a member of Lithuania Academy of Sciences and has been awarded by the Lithuania Science Prize. During his research leave at Max Planck Institute of Biochemistry with Professor Robert Huber he became interested in structural biology. Dr. Siksnys made a major contribution to the understanding of the structure and function of restriction enzymes. His current research interests are focused on the mechanisms of the CRISPR antiviral defence system and development of novel molecular tools for genome editing.

Selected Publications:

1. Sukackaite R, Grazulis S, Tamulaitis G, Siksnys V. The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine. Nucleic Acids Res. 2012, 40: 7552-62.
2. Gasiunas G, Barrangou R, Horvath P, Siksnys V. Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci U S A. 2012, 109: E2579-86.
3. Sinkunas T, Gasiunas G, Waghmare SP, Dickman MJ, Barrangou R, Horvath P, Siksnys V. In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus. EMBO J. 2013; 2:385-94.
4. Gasiunas G, Siksnys V. RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing? Trends Microbiol. 2013, 21:562-7.
5. Szczelkun MD, Tikhomirova MS, Sinkunas T, Gasiunas G., Karvelis T., Pschera P., Siksnys V., Seidel R. Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes. Proc Natl Acad Sci U S A. 2014, in press.

Important Dates



30 May
5 June

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