„Young biochemistry“

17 June, 2014 | Birštonas


Lolita Zaliauskienė
(R&D Manager, Thermo Fisher Scientific Baltics)

Education: Vilnius State University M.S. Genetics 1987
University of Alabama at Birmingham Ph. D. Cell Biology 2002

Positions: unior Engineer-Geneticist, Institute of Biotechnology, Vilnius, Lithuania 1987-1995
Research Assistant, Dept. of Cell Biology, UAB 1995-1997
Postdoctoral Fellow, Dept. of Cell Biology, UAB 2002-2004
Postdoctoral Fellow, Dept. of Pathology, UAB 2004-2006
R&D Manager, R&D Center, Thermo Fisher Scientific Baltics, Vilnius, Lithuania Current

Research Experience: 1984-1987, Vilnius State University, research project: Protein analysis of high lysine barley mutant lines". Principal investigator Prof. V.Rancelis
1987-1995, Institute of Biotechnology, Laboratory of Enzyme Biosynthesis. Projects: Penicillium citrinum - producer of nuclease S1 - mutagenesis. Cloning the gene for thioredoxine, the subunit of T7 DNA polymerase. Maintenance of bacterial strains - producers of various modification enzymes.
1995-2004, University of Alabama at Birmingham, Dept. of Cell Biology, Laboratory of Dr. J.Collawn. Projects: Generation and functional characterization of CFTR-TR chimeras, TR-GFP and Ii-GFP mutants. Analysis of antigen delivery into antigen presenting cells by conjugating peptide antigens to carrier proteins.
2004-2006, University of Alabama at Birmingham, Dept. of Pathology, Laboratory of Dr. C.T.Weaver. Projects: (a) Analysis of helper T cell interactions, (b) dendritic cell influence on regulatory T cell suppressive properties, (c) involvement of costimulatory and adhesion molecules in control of regulatory T cell function.

Scientific Interests: Macromolecule internalization and trafficking within the cell. Modulation of helper T cell responses with emphasis on cell- and immuno-therapeutics.

Awards: Research Development Award, Office of Postdoctoral Education, University of Alabama at Birmingham 2003-2004

Publications: 1. Zaliauskiene, L., Bernadisiute, U., Vareikis, A., Makuska, R., Volungeviciene, I., Petuskaite, A., Riauba, L., Lagunavicius, A., Zigmantas, S. (2010). Efficient Gene Transfection Using Novel Cationic Polymers Poly(Hydroxyalkylene Imines). Bioconjug Chem., 2010 Sep 15; 21(9):1602-11. PMID: 20695432
2. Bebok, Z., Varga, K., Zaliauskiene, L., Schwiebert E.M. and Collawn, J. F. (2003). Protein Trafficking: Studies on the Transferrin Receptor (TR) and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). (Book Chapter) Recent Devel. Cell Res., 1: 203-216 ISBN: 81-271-0006-4.
3. Collawn, J.F., Zaliauskiene, L., Benveniste, E.N. (2003). Interferons. In: Encyclopedia of Neurological Sciences. M. Aminoff and R. Daroff (eds). Academic Press, San Diego, CA. Vol. 2, 674-680.
4. Zaliauskiene, L., Fazio, R.L., Kang, S., Sparks, K., Zinn, K.R., Weaver, C.T., and Collawn, J.F. (2002) Inhibition of T cell Responses by Transferrin-coupled Competitor Peptides. Immunol. Res. 26:297-305.
5. Zaliauskiene, L., Kang, S., Sparks, K., Zinn, K.R., Schwiebert, L.M., Weaver, C.T., and Collawn, J. F. (2002) Enhancement of MHC Class II-restricted Responses by Receptor-Mediated Uptake of Peptide Antigens. J. Immunol. 169:2337-2345.
6. Zaliauskiene, L., Kang, S., Brouillette, C. G., and Collawn, J. F. (2000) Down-regulation of Cell Surface Receptors is Modulated by Polar Residues within the Transmembrane Domain. Mol. Biol. Cell 11:2643-2655.
7. Prince, L. Peter, K., Hatton, S., Zaliauskiene, L., Cotlin, L. F., Clancy, J. P., and Collawn, J. F. (1999). Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal. J. Biol. Chem. 274:3602-3609.

International patents: 1. Lagunavicius, A., Zigmantas, S., Riauba, L., Zaliauskiene, L., Makuska, R., Vareikis, A. & Bernadisiute, U. Transfection reagent. 12.12.2007/ GB20070724253; 08.12.2008/ EP20080170995, 17.06.2009/ EP2070970A2; 02.18.2010/US2010/0041739A1.
2. 2. Lagunavicius, A. & Zaliauskiene, L. Protein delivery agent, 12.10.2009/ GB0917792; 04.14.2011/US2011/0086794A1.
3. 3. Siksnys, V., Gasiunas, G., Karvelis, T., Lubys, L., Zaliauskiene, L., Glemzaite, M., Smith, A. "RNA- directed DNA cleavage by the Cas9-crRNA complex", WO2013142578A1, PCT/US2013/033106.

Important Dates



30 May
5 June

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