Skaitliukas KontaktaiTyrimaiBendradarbiavimasProjektai Publikacijos Paskaitos  

Baltymų ir epigenominių tyrimų grupė


  1. Treigytė G., R. Navakauskienė, A. Kulytė, A. Gineitis and K.-E. Magnusson. Tyrosine phosphorylation of cytoplasmic proteins in proliferating, differentiating, apoptotic HL-60 cells and blood neutrophils. Cell. Mol. Life Sci. 57:1997-2008, 2000. 

  2. Kulytė, A. Navakauskienė, G. Treigytė, A. Gineitis and K.-E. Magnusson. Parallel assessment of tyrosine phosphorylation and nuclear targetting of proteins. BioTechniques 31: 510, 512-514, 517, 2001.

  3. Kulytė A., R. Navakauskienė, G. Treigytė, A. Gineitis, T. Bergman and K.-E. Magnusson. Characterization of human alpha-dystrobrevin isoforms in HL-60 human promyelocytic leukemia cells undergoing granulocytic differentiation. Mol. Biol. Cell. 13: 4195-4205, 2002.

  4. Navakauskienė R., G. Treigytė, A. Gineitis and K.-E. Magnusson. Assessment of p16, p21 and p27 in granulocytic differentiation of human promyelocytic HL-60 cell line. Ann. NY Acad. Sci. 973: 284-286, 2002. 

  5. Navakauskienė R., A. Kulytė, G. Treigytė, A. Gineitis and K.-E. Magnusson. Translocation of transcription regulators into the nucleus during granulocyte commitment of HL-60 cells. Biochem. Cell Biol. 81: 285-295, 2003. 

  6. Navakauskienė R., G. Treigytė, A. Gineitis and K.-E. Magnusson. Elucidation of tyrosine-phosphorylated proteins of apoptotic origin in HL-60 cell line. Proteomics 4:1029-1041, 2004. 

  7. Navakauskienė R., G. Treigytė, J. Savickienė, A. Gineitis  and K.-E. Magnusson. Alterations in protein expressions in HL-60 cells during etoposide-induced apoptosis modulated by the caspase inhibitor ZVAD.fmk. Ann. NY Acad. Sci. 1030: 393-402, 2004.  

  8. Savickienė J., G. Treigytė, A. Pivoriūnas, R. Navakauskienė and K.-E. Magnusson.  Monocytic differentiation and apoptosis of promyelocytic leukemia: alterations in Sp1 and NF-kB transcription factors activity. Ann. NY Acad. Sci. 1030: 568-576, 2004.  

  9. Savickienė J., G. Treigytė,  K.-E. Magnusson and R. Navakauskienė. p21 (Waf1/Cip1) and FasL gene activation via Sp1 and NFkB is required for leukemia cell survival but not for cell death induced by diverse stimuli. Intern. J. Biochem. Cell Biol. 37:784-796, 2005.  

  10. Meržvinskytė R., G. Treigytė,  J. Savickienė, Magnusson K.-E. and R. Navakauskienė. Effects of histone deacetylase inhibitors, sodium phenyl butyrate and vitamin B3, in combination with retinoic acid on granulocytic differentiation of human promyelocytic leukemia HL-60 cells. Ann. NY Acad. Sci. 1091:356-367, 2006.  

  11. Savickienė J., G. Treigytė , V.V. Borutinskaitė, R. Navakauskienė and K.-E. Magnusson. The histone deacetylase inhibitor FK228 sensitizes distinctly the human leukemia cells to retinoic acid-induced differentiation. Ann. NY Acad. Sci. 1091:368-384, 2006. 

  12. Borutinskaitė V.V., R. Navakauskienė and Magnusson K.-E. Retinoic acid and histone deacetylase inhibitor BML-210 inhibit proliferation of human cervical cancer HeLa cells. Ann. NY Acad. Sci.  1091:346-355, 2006.  

  13. Savickienė J., V.V. Borutinskaitė, G. Treigytė, K.-E. Magnusson and R. Navakauskienė. The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects in the human leukemia cell lines. Eur. J. Pharmacol. 549:9-18, 2006. 

  14. Pivoriūnas A., J. Savickienė, G. Treigytė, V. Tunaitis, R. Navakauskienė and K.-E. Magnusson. PI 3-K signaling pathway supresses PMA-induced expression of p21WAF1/Cip1 in human myeloid cells. Mol. Cell. Biochem. 302:9-18, 2007. 

  15. J. Savickiene, G. Teigyte, K.-E. Magnusson, R. Navakauskiene. Response of retinoic-acid-resistant KG1 cells to combination of retinoic acid with diverse pistone deacetylase inhibitors. Ann. NY Acad. Sci. 1171: 321-333, 2009.

  16. A. Pivoriūnas, A. Surovas, V. Borutinskaitė, D. Matuzevičius, G. Treigytė, J. Savickienė, V. Tunaitis, R. Aldonytė, A. Jarmalavičiūtė, K. Suriakaitė, E. Liutkevičius, A. Venalis, D. Navakauskas, R. Navakauskienė, K.E. Magnusson. Proteomic analysis of stromal cells derived from the dental pulp of human exfoliated deciduous teeth. Stem Cells & Developmental. 19: 1081-1093, 2010.

  17. J. Savickiene, G. Teigyte, A. Gineitis, R. Navakauskiene. A critical role of redox state in determining HL-60 cell granulocytic differentiation and apoptosis via involvement of PKC and NF-kappaB. In Vitro Cell. Dev. Biol. Anim. 46: 547-559, 2010.

  18. J. Savickiene, G. Treigyte, C. Aleksandraviciene, R. Navakauskiene. Low-dose ionizing radiation effects on differentiation of HL-60 cells. C. Eur. J. Biol. 5: 600-612, 2010.

  19. J. Savickiene, G. Treigyte, G. Vistartaite, V. Tunaitis, K.-E. Magnusson and R. Navakauskiene. C/EBPa and PU.1 are involved in distinct differentiation responses of acute promyelocytic leukemia HL-60 and NB4 cells via chromatin remodelling. Differentiation. 81: 57-67, 2011.

  20. V.V. Borutinskaite, K.-E. Magnusson, R. Navakauskiene. Alpha-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation. Molecular Biology Reports. 38: 3001-3011, 2011.

  21. V. Tunaitis, V. Borutinskaite, R. Navakauskiene, G. Treigyte, A. Unguryte, R. Aldonyte, K.-E. Magnusson and A. Pivoriūnas. Effects of different sera on adipose tissue-derived mesenchymal stromal cells. Journal of Tissue Engineering and Regenerative Medicine. 5: 733-746, 2011

  22. J. Savickiene, G. Treigyte, V. Jonusiene, R. Bruzaite, V.V. Borutinskaite, R. Navakauskiene. Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells. Mol Cell Biochem. 359: 245-261, 2012.

  23. R. Navakauskiene, G. Treigyte, V. Borutinskaite, D. Matuzevicius, D. Navakauskas, K.-E. Magnusson. Alpha-Dystrobrevin and its associated proteins in human promyelocytic leukemia cells induced to apoptosis. J Proteomics. 75: 3291-3303, 2012.

  24. J. Savickiene, G. Treigyte, V.V. Borutinskaite, R. Navakauskiene. Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells. Cell Mol Biol Lett. 17: 501-525, 2012.

  25. J. Savickiene, G. Treigyte, A. Jazdauskaite, V.V. Borutinskaite, R. Navakauskiene. DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodeling. Cell Biol Int. 36: 1067-1078, 2012.

  26. V.V. Borutinskaite, K.-E. Magnusson, R. Navakauskiene. Histone deacetylase inhibitor BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Mol Biol Rep. 2012, vol. 39 (12), p. 10179-10186.

  27. J. Savickiene, G. Treigyte, I. Stirblyte, G. Valiuliene, R. Navakauskiene. Euchromatic histone methyltransferase 2 inhibitor, BIX-01294, sensitizes human promyelocytic leukemia HL-60 and NB4 cells to growth inhibition and differentiation. Leukemia Res. 2014, vol. 38 (7), p. 822-829.

  28. J. Savickiene, G. Treigyte, G. Valiuliene, I. Stirblyte, R. Navakauskiene. Epigenetic and molecular mechanisms underlying the antileukemic activity of the histone deacetylase inhibitor belinostat in human acute promyelocytic leukemia cells. Anti-Cancer Drugs. 2014, vol. 25(8), p. 938-949.

  29. R. Navakauskiene, V.V. Borutinskaite, G. Treigyte, J. Savickiene, D. Matuzevicius, D. Navakauskas, K.-E. Magnusson. Epigenetic changes during hematopoietic cell granulocytic differentiation--comparative analysis of primary CD34+ cells, KG1 myeloid cells and mature neutrophils. BMC Cell Biology. 2014, vol. 15(4), p. 938-949.

  30. G. Treigyte, I. Zaikova, D. Matuzevicius, V. Ceksteryte, G. Dabkeviciene, B. Kurtinaitiene, R. Navakauskiene. Comprehensive proteomic analysis of white (Trifolium repens L.), berseem (Trifolium alexandrinum L.) and red (Trifolium pratense L.) clovers pollen. Zemdirbyste-Agriculture. 2014, vol. 101(4), p. 453-460.

  31. G. Valiuliene, I. Stirblyte, D. Cicenaite, A. Kaupinis, M. Valius, R. Navakauskiene. Belinostat, a potent HDACi, exerts antileukemic effect in human acute promyelocytic leukemia cells via chromatin remodelling. Journal of Cellular and Molecular Medicine. 2015, doi: 10.1111/jcmm.12550.

  32. I. Karpavičienė, G. Valiulienė, V. Raškevičius, I. Lebedytė, A. Brukštus, V. Kairys, R. Navakauskienė, I. Čikotienė. Synthesis and antiproliferative activity of α-branched α,β-unsaturated ketones in human hematological and solid cancer cell lines. European Journal of Medicinal Chemistry. 2015, vol. 98, p. 30-48.

  33. Borutinskaitė V, Navakauskienė R. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. International Journal of Molecular Sciences. 2015, vol. 16(8):18252-18269.

  34. Savickiene J, Treigyte G, Baronaite S, Valiuliene G, Kaupinis A, Valius M, Arlauskiene A, Navakauskiene R. Human Amniotic Fluid Mesenchymal Stem Cells from Second- and Third-Trimester Amniocentesis: Differentiation Potential, Molecular Signature, and Proteome Analysis. Stem Cells International. 2015, vol. 2015:319238. doi: 10.1155/2015/319238.

  35. G. Valiuliene, G. Treigytė, J. Savickienė, D. Matuzevičius, M. Alksnė, R. Jarašienė-Burinskaja, V. Bukelskienė, D. Navakauskas, R. Navakauskienė. Histone modifications patterns in tissues and tumours from acute promyelocytic leukemia xenograft model in response to combined epigenetic therapy. Biomedicine & Pharmacotherapy. 2016, vol. 79:62–70.