Speakers

Vytautas Smirnovas
(IBT VU, Vilnius)

Senior scientist (since 2011)
Principal Investigator (since 2012)
Department of Biothermodynamics and Drug Design
Vilnius University Institute of Biotechnology

Education and professional experience: PostDoc, Dept. Physiology and Biophysics, Case Western Reserve University, Clevealnd, OH, USA (2008 - 2011), PhD, Biophysical Chemistry group, Dept. Physical Chemistry, Dortmund Technical University, Germany (2004 - 2007), Internship, Protein Biophysics Group, Inst. High Pressure Physics, Polish Academy of Sciences, Poland (2003 - 2004), MSc in bioengineering, Vilnius Gediminas Technical University, Lithuania (2000 - 2002), BSc in biotechnology, Vilnius Gediminas Technical University, Lithuania (1996 - 2000).

Professional interests: protein misfolding, amyloid fibril formation, prions and proteinaceous infectivity.

Publications:
Milto K, Michailova K, Smirnovas V (2014) Elongation of mouse prion protein amyloid-like fibrils: effect of temperature and denaturant concentration. PLoS One 9(4):e94469.
Milto K, Botyriute A, Smirnovas V (2013) Amyloid-Like Fibril Elongation Follows Michaelis-Menten Kinetics. PLoS One 8:e68684.
Smirnovas V et al. (2011) Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nature structural & molecular biology 18:504-506.
Smirnovas V et al. (2009) Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. The Journal of biological chemistry 284:24233-41.
Smirnovas V, Winter R (2008) Revealing different aggregation pathways of amyloidogenic proteins by ultrasound velocimetry. Biophysical journal 94:3241-6.